Xanthogranulomatous cholecystitis (XGC) is an uncommon The files of the department of histopathology at the. Royal Hallamshire Hospital. Xanthogranulomatous cholecystitis is a rare inflammatory disease of in a review of 40 cases from the Armed Forces Institute of Pathology [3]. General. Uncommon ~ %. Approximately 2% in one series of gallbladders. May be confused (clinically) with gallbladder carcinoma.

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Hepatobiliary Pancreat Dis Int 11 5: Navigation Main page Recent changes Random page Help. The patient was discharged on postoperative day 10 without complications. Preoperative diagnosis of xanthogranulomatous cholecystitis.

XGC may be a high risk of postoperative wound infection and other septic complications because of frequent adhesion and abscess formation. Ultrasonographic examination showed an inhomogenous, hypoechoic wall thickening of the gallbladder with internal small stones and no dilatation of intrahepatic bile ducts Fig.

Dissection between xanthogeanulomatous gallbladder serosa and hepatic parenchyma was difficult. The pathogenesis of XGC is uncertain, but histologic evidence of chronic inflammation is generally seen histopwthology gallstones are present in a large majority of cases.

Genetic analysis of histipathology cholecystitis: Yellow brown, poor to well demarcated foci of wall thickening with variable ulceration, simulates neoplasm. Postgrad Med J ; Perfidious gallbladders – a diagnostic dilemma with xanthogranulomatous cholecystitis.

DDx gallbladder carcinomaacute cholecystitis Treatment cholecystectomy surgical removal Xanthogranulomatous cholecystitis xanthogranuoomatous, abbreviated XGC[1] is an uncommon pathology of the gallbladder. Gallstones are present in most patients. J Radiol Case Rep 5 4: Occasionally, XGC may closely mimic a gallbladder cancer or lead to complications such as perforation, abscess and fistula.


In conclusion, XGC is difficult to differentiate from other forms of cholecystitis and, sometimes, from gallbladder cancer, clinically and radiologically. On xanthogranulkmatous cholangiogram through the cystic duct after cholecystectomy, there was no evidence of remaining stone or bile duct dilatation.

No metaplasia, dysplasia or significant nuclear atypia is apparent. Abstract Xanthogranulomatous cholecystitis XGC is an uncommon, focal or diffuse destructive inflammatory disease of the gallbladder that is assumed to be a variant of histoapthology chronic cholecystitis.

Rebound tenderness or hepatosplenomegaly was not found.

Hyperplasia, atypical hyperplasia and carcinoma in situ. Xanthogranulomatous cholecystitisabbreviated XGC[1] is an uncommon pathology of the gallbladder. Pathology of Xanthogranulomatous Cholecystitis.

There were multiple black pigmented gallstones ranging from 0. No metaplasia, nuclear atypia or dysplasia is apparent.

A prospective study of 31 cholecystiis. It means that both XGC and gallbladder cancer are complications of gallstone and inflammation of the gallbladder, or it may suggest that tissue disruption by cancer facilitates extravasation of bile into the gallbladder wall Radiologic findings in xanthogranulomatous cholecystitis.

histopzthology A retrospective Cohort study. Benign tumors and pseudotumors of the gallbladder: Xanthogranulomatous cholecystitis ; Gallbladder cancer. Gastroenterol Res Pract Dr Sampurna Roy MD.

Xanthogranulomatous cholecystitis. Histopathological study and classification.

Cytopathologic diagnosis of xanthogranulomatous cholecystitis and coexistent lesions. XGC is characterized grossly by irregular wall thickening of the gallbladder associated with the formation of yellowish nodules. On admission, the patient was febrile and had tenderness on deep palpation to the right upper quadrant. There was a small-sized abscess in the gallbladder wall near the cystic duct. Foamy macrophages or macrophages with ceroid, bile or iron Also cholesterol clefts and multinucleated giant cells May be focal, nodular or diffuse May contain lymphocytes, plasma cells, foreign body giant cells and neutrophils.


Gallbladder Cholecystiis Xanthogranulomatous cholecystitis Author: It has been suggested that XGC is initiated by a chronic inflammation and obstruction.

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The most useful indication of percutaneous needle biopsy would, perhaps, be in advanced gallbladder cancer, as unnecessary laparotomy could be avoided. Clinico-pathological study of xanthogranulomatous cholecystitis. XGC may be difficult to distinguish clinically from acute or chronic cholecystitis; cholfcystitis, it is difficult to distinguish from gallbladder cancer.

Xanthogranulomatous cholecystitis histopathollogy a destructive inflammatory disease of the gallbladder, rarely involving adjacent organs and mimicking an advanced gallbladder carcinoma. This page was last modified on 30 Mayat Clinical manifestations of XGC are usually those of acute or chronic cholecystitis, but some patients present anorexia, nausea, vomiting, right upper quadrant pain and mass, suggesting gallbladder cancer.

Am J Surg Pathol ;5: The true incidence of XGC is difficult to ccholecystitis because this disease is apparently a rare condition, although retrospective estimates of the incidence in cholecystectomy specimens range from 0. Grossly the lesions are usually soft, yellow to brown, and measure up to 2.

We report a case with XGC mimicking gallbladder cancer in a hemophilia patient. A previously undescribed lesion.

Pathology Outlines – Xanthogranulomatous cholecystitis

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Surgical treatment of xanthogranulomatous cholecystitis: