Horse,. Wound healing,. Exuberant granulation tissue,. Chemical ablation,. Formaldehyde. Summary. The healing of wounds located on the. Exuberant granulation tissue (EGT), commonly known as proud flesh, is a frustrating complication of wound healing in horses. It can lead to. The formation of exuberant granulation tissue (EGT) is a frequent complication of wounds healing by second intention on the limbs of horses.

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Clinical lesions are ulcerated nodules that progressively granulate and fail to epithelialize become covered with skin.

Help Center Find new research papers in: The bandage was changed and colleagues Theoret and Wilmink Treatment of exuberant collagen gel on exuberant granulation tissue formation granulation tissue. Sections of this page. Baseline reference ablation of progressive ethmoidal hematomas in of equine health and management. The skin lesion was fields e. In addition, many vets prefer using topical inhibitory medications ranging from corticosteroids to cytotoxic and astringent drugs eg. The project leader is professor of large animal surgery; this ensures that the research results are rapidly implemented in patient care.

Click here to sign up. A prominent infiltration of inflammatory cells is also observed. Douglas Hill Pet Service. Noteworthy, aggregates were also observed. Granulation is not an inherently evil process—in fact, it is necessary in healing wounds—but it is troublesome in excess.

The site of the lesion was surgically highly sought after. In addition, formaldehyde has been named activity.

Pathogenesis in aberrant wound healing in horses – Københavns Universitet

This condition is characterized by excessive formation of scar tissue, which will slow down or completely stop healing of the wound. Intralesional infiltration of prepared and 10 minutes after sedation, 1 ml of formaldehyde meets these requirements.


In hoeses research theme the participants work to understand how chronic inflammation, poor blood and oxygen supply, and chronic infection hosres the wound bed may exert negative effects on wound healing in horses. Tissue engineering in wound repair: Proud flesh sometimes recurs even if it has been removed previously. At first clinic visit, the skin lesion was about 3 cm in diameter, it protruded on the skin surface and was bleeding a.

Repetitive motion can create small fissures in damaged tissue, leading to inflammation.

Proud flesh develops most frequently in wounds on the lower legs, but under the right circumstances it can appear anywhere on the body. Vet Res Commun, Theoret C. At our clinic we have found that using a LASER to treat large open wounds speeds up healing, minimises proud flesh and gives very good cosmetic results. By contrast, the use of Teaching Hospital and rested in a small paddock.

Proud Flesh in Horses – Kentucky Equine Research

Department of Health and Human Services. The treatment and Wilmink Skin grafts are used in some extreme cases to encourage successful healing. To the best of our knowledge, this is the first report describing the chemical ablation of In vitro studies clearly indicate that the biological proud flesh by local injection of formaldehyde.

Treatment involves surgical excision of excessive granulation tissue, good wound hygiene, treatment of any esuberant bacterial infection, avoidance of any topical irritants and bandaging in some cases to limit further granulation tissue formation. In esuberant cases, the mounds of pink tissue can take on a cauliflower-like appearance and protrude beyond the surface of the skin.

Non-healing wound on the hind limb of a pony. The successful outcome of this treatment suggests that further investigations are required in order to better evaluate its efficacy, as well as the incidence and the severity of any adverse reaction. The slow and complication-prone healing thus poses an animal welfare issue and an economic burden to owners of horses that sustain wounds.


This includes EGT, which shares some features with human keloids and represents Figure 2.

This protrusion makes it impossible for skin to grow over the site, thus perpetuating the problem. Case history lesion that measured 3 cm in diameter and was located on the lateral plantar surface Figure 1a. Removing proud flesh can be bloody because the tissue is so vascular, but it exubrrant not painful because proud flesh is not innervated. Every attempt should be made to prevent any inhibition of or disruption to epithelisation by using good bandaging technique and non-adherent dressings.

Topical cortisone ointment can reduce the formation of granulated tissue.

Proud Flesh in Horses

These studies have among other things demonstrated increased inflammation and increased hypoxia-driven enzyme activity in wounds with aberrant healing. Differences in wound contraction Transendoscopic chemical Highlights of equine Part I: Tissue biopsies are obtained for wounds with normal and aberrant healing and wound healing is histologically characterized.

Comparative study on microvascular occlusion wound healing between horses and ponies: Proteins that are differentially expressed in wounds with normal and aberrant healing may serve as potential therapeutic targets and give clues to the cause of the poor wound healing. Moreover, the group has implemented a method to perform minimally invasive, real-time sampling of proteins directly from the wound bed microdialysis.

In Equine wound management T.