Read the Patient/Caregiver Information Leaflet provided by your pharmacist before (including prescription drugs, nonprescription drugs, and herbal products). Diastat. This web page is intended as quick reference of limited prescribing information for this product. This is not intended to represent a comprehensive. The syringe(s) should be labeled with appropriate information including the .. Avoid prescribing opiate cough medications in patients taking benzodiazepines.

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Moderate Drugs that can cause CNS depression, if used concomitantly with asenapine, may increase both the frequency and the intensity of adverse effects such as drowsiness, sedation, and dizziness.

MAOIs can cause a variable change in seizure patterns, so careful monitoring of the patient with epilepsy is required when benzodiazepines are used in the treatment of epilepsy. Concurrent use of topiramate and benzodiazepines associated with thrombocytopenia e.

One infant exposed to diazepam 30 mg daily at 5 days postpartum experienced weight loss, lethargy, and electroencephalogram EEG findings consistent with a sedative medication. Instruct patients receiving these medications concurrently not to drive or operate machinery.

Concomitant use of fenofibric acid with CYP2C19 substrates, such as diazepam, has not been formally studied.

To minimize potential for interactions, consider administering oral anticonvulsants at least 1 hour before or at least 4 hours after colesevelam. Moderate Co-administration of dexmedetomidine with benzodiazepines is likely to lead to an enhancement of CNS depression. presceibing

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All diazepam formulations are contraindicated in patients with closed-angle glaucoma. Dose reductions may be required. If any benzodiazepine is used by a breast-feeding mother, monitor the infant for adverse effects, such as sedation. Major Use caution if diazepam and aprepitant, fosaprepitant are used concurrently and monitor for an increase in diazepam-related adverse effects for several days after administration of a multi-day aprepitant regimen.


Administration should commence promptly and be completed within 6 hours after the ampules have been opened. Major Use caution if mitotane and diazepam are used concomitantly, and monitor for decreased efficacy of diazepam and a possible change in dosage requirements. The one patient who died had ingested the largest total dose 15 g of chloroquine. Moderate Ketoconazole could theoretically inhibit CYP3A4 metabolism of oxidized benzodiazepines such as diazepam.

Ensure that both the cap and seal pin are removed. Moderate Concomitant administration of benzodiazepines with eszopiclone can potentiate the CNS effects e.

Diazepam can cause physical and psychological dependence, and should be used with extreme caution in patients with known, suspected or a history of substance abuse.

However, it would be prudent to monitor patients more closely, particularly if other CNS depressants are prescribed.

Moderate Close clinical monitoring is advised when administering diazepam with telaprevir due to an increased potential for diazepam-related adverse events. Belladonna Alkaloids; Ergotamine; Phenobarbital: Caution should be used when asenapine is given in combination with other centrally-acting medications including anxiolytics, sedatives, and hypnotics including barbituratesbuprenorphine, buprenorphine; naloxone, butorphanol, dronabinol, THC, nabilone, nalbuphine, opiate agonists, pentazocine, acetaminophen; pentazocine, aspirin, ASA; pentazocine, and informaation naloxone.

Moderate Use clobazam with other benzodiazepines with caution due to the potential for increased risk informaiton drowsiness and sedation. A pharmacist must Dial in the Dose and Lock the rectal syringe prior to dispensing the product to the patient.


Diastat (diazepam) dose, indications, adverse effects, interactions from

Children 6 – 11 years. Moderate Fluconazole could theoretically inhibit CYP3A4 metabolism of oxidized benzodiazepines, such as diazepam.

Asthma, chronic obstructive pulmonary disease COPDcoadministration with other CNS depressants, pulmonary disease, respiratory depression, respiratory insufficiency, sleep apnea. Consider dose reduction of diazepam if clinically indicated. Keep person on the side facing you, note time given and continue to observe. If a benzodiazepine must be used in a patient with a history of falls or fractures, consider reducing use of other CNS-active medications that increase the risk of falls and fractures and implement other strategies to reduce fall risk.

Moderate Additive CNS depression may occur when oxybutynin is used concomitantly with other CNS-depressant drugs, including anxiolytics, sedatives, and hypnotics. The dose of any opiate agonist administered with parenteral diazepam should be reduced by at least one-third. These duastat used in combination may result in elevated diazepam plasma concentrations, causing an increased risk for diazepam-related adverse events.

Ribociclib is a strong CYP3A4 inhibitor. Acetaminophen; Chlorpheniramine; Phenylephrine; Phenyltoloxamine: Diasgat esomeprazole is an inhibitor of the CYP2C19 isozyme, plasma levels of diazepam may increase.