Cotula cinerea Del. belongs to the family Asteraceae. It is widely used in the traditional medicinal system for the treatment of various ailments such as colic. Cotula cinerea Delile [family COMPOSITAE ] (stored under name); Verified by Not on Brocchia kotschyi; Cotula kotschyi; Cotula cinerea; Brocchia cinerea. Abstract: The phytochemical investigation of Cotula cinerea Del. afforded eighteen Keywords: Cotula cinerea Del.; Asteraceae; Flavonoids; Germacranolide.
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The evaluation of cell viability has been achieved through the use of MTT 3- 4,5-dimethylthiazol-2,5-diphenyl tetrazolium bromide assay. Higher concentrations were needed in the case of Salvia verbenaca extracts which showed the weakest cytotoxic effects. In addition, these mixtures could act in a synergic or in an antagonism manner. The extraction was achieved during six hours and the obtained oil yield 0.
In an ongoing program aimed at the exploration of the phytochemical compounds and the biological activities of medicinal plants of Morocco, we were interested, in this work, in the cytotoxic effect of Cotula cinerea and Salvia verbenaca. Essential oils are complex molecules containing various and several terpenoids compounds belonging mainly to monoterpene and sesquiterpene chemical groups and presenting different functional groups such as alcohols, phenols, ketone, etc.
Cotula – Wikipedia
Nevertheless, the Cotula cinerea essential oil can act through various mechanisms. Despite the appreciable advancements and progress made in cancer treatment, it continues to constitute a serious global health problem, especially with the appearance of multidrug resistance cells.
This work was therefore initiated in order to evaluate clnerea in vitro antiproliferative effect of Cotula cinerea ctoula Salvia verbenaca extracts and essential oil against ctoula RD and Vero cell lines. The plant is widely distributed in Morocco and is widely used in Moroccan traditional folk medicine as a cholagogue, antiseptic, diuretic, and astringent [ 12 ]. Traditional forms of medicine, especially the herbal products deployed for centuries in many parts of the world, could be good alternative for scientific investigation due to their attributes against tumor cell dinerea.
This study is expected thus to be beneficial for clinical and traditional applications for Cotula cinerea as a remedy against cancer and opens new perspectives for further exploration on other types of cancer cell lines. Voucher specimens of both plants were deposited in the herbarium of the Botany Department of this institution.
These plants are widely used in the Moroccan traditional folk medicine. Antibacterial activity of silver nanoparticles synthesized by using whole plant extracts of Clitoria ternatea. In the genus was subdivided by George Bentham  into three sections.
Chemical composition and Anticandidal properties of the essential oil isolated from aerial parts of Cotula Cinerea: The collected aerial parts were left under shade at room temperature until complete drying. Further studies are obviously needed to elucidate the exact mechanism of Cotula cinerea in cytotoxic activity. Retrieved 24 August Cotula is known to be used in New Zealand as ground cover for bowling greens, playing fields on which the ball-game of bowls is played  .
It is thus important and imperative to find more effective drugs with a shorter application period. Cothla of Salvia verbenaca were collected on March at the locality called Ain Aouda, in cinreea Rabat region, Morocco.
Another characteristic is their solitary heads growing on a peduncle.
Results and Discussion In an ongoing program aimed at the exploration of the phytochemical compounds and the biological activities of medicinal plants of Morocco, we were interested, in this work, in the cytotoxic effect of Cotula cinerea and Salvia verbenaca. Cotula socialis Hilliard Cotula sororia DC.
From Wikipedia, the free encyclopedia. Cancer is a complex disease caused cottula several factors such as genetic deregulation, environmental influencing agents, and epigenetic modification factors [ 12 ].
In the same conditions and for the Vero cell line, the best cytotoxic effect was observed with the essential oil followed by the hexane, the ethyl acetate, and the n -butanol extracts. In other projects Wikimedia Commons Wikispecies. Retrieved from ” https: An examination of the obtained results showed that the cytotoxic effects of the investigated plants extracts were different according to the tested cell line with an efficient activity of Cotula cinerea compared to Salvia verbenaca.
The enumeration of cells coyula made using Malassez cell count. The essential oil and the ethyl acetate extract showed moderate cytotoxic effects The test is based on the biotransformation of MTT into formazan crystals by mitochondrial dehydrogenases of living cells. The results are expressed as percentage of cytotoxicity versus the concentrations of the essential oil or extracts of both plants.
Koch Cotula cinereum Cotula coronopifolia L. According to the World Health Organization, incidence and mortality due to cancer are widely increasing in the world [ 3 ]. Further investigations regarding the identification of bio-actives molecules responsible for these effects are needed.
Antiproliferative activity at different concentrations of the essential oil and different extracts of Cotula cinerea top and Salvia verbenaca bottom against Vero cell line by MTT assay.
Composition chimique et isolement des deux principaux constituants. Cotula macroglossa Bolus ex Schltr. This was followed by the ethyl acetate extract and the essential oil with moderate effects against RD cell line and showed IC 50 values of The species within this genus can vary extensively in their habitleaf divisioninvolucrereceptacle and achenes. Introduction Cancer is a cotul disease caused by several factors such as genetic deregulation, environmental influencing agents, and epigenetic modification factors [ 12 ].
The exact mechanism through which the explored extracts act on each tumor cell line is obviously difficult to highlight.
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Correspondence should be addressed to Fatima-Ezzahrae Guaouguaou ; moc.